Human laminin isolated in a nearly intact, biologically active form from placenta by limited proteolysis.
نویسندگان
چکیده
منابع مشابه
P66: A Biologically Active Motif of Laminin for Spinal Cord Regeneration
لطفاً به چکیده انگلیسی مراجعه شود.
متن کاملProbing Conformational Feature of a Recombinant Pyruvate Kinase by Limited Proteolysis
Pyruvate kinase is a key enzyme in glycolytic pathway that catalyzes the transphosphorylation between phosphoenolpyruvate and ADP to yield ATP and Pyruvate. Geobacillus stearothermophillus has a stable pyruvate kinase with determined crystal structure that composed of four separate domains. Given that limited proteolysis experiments can be successfully used to probe conformational features of p...
متن کاملInterleukin-2 is Present in Human Blood Vessels and Released in Biologically Active Form by Heparanase
Interleukin-2 (IL-2) is a multifaceted cytokine with immunostimulatory and immunosuppressive properties. Our laboratory recently demonstrated that the availability of IL-2 is regulated, in part, by association with perlecan, a heparan sulfate proteoglycan. Given the abundance of perlecan in blood vessels, we asked whether IL-2 is present in vessel walls. Our results indicate that IL-2 is associ...
متن کاملIsolation of biologically active Actinomycetes from untouched soils: a case study from Karaj district, Iran
Actinomycetes are a source of a broad variety of secondary metabolites with diverse biological activities, such as antifungi, antibiotics and antitumorals; many of which have been developed for clinical use. In this study, 34 actinomycetes from untouched soils were isolated from Alborz Province-Iran. Evaluation ofantifungal and anti bacterial activities of these isolates, demonstrated the capab...
متن کاملNewly identified biologically active and proteolysis-resistant VEGF-A isoform VEGF111 is induced by genotoxic agents
Ultraviolet B and genotoxic drugs induce the expression of a vascular endothelial growth factor A (VEGF-A) splice variant (VEGF111) encoded by exons 1-4 and 8 in many cultured cells. Although not detected in a series of normal human and mouse tissue, VEGF111 expression is induced in MCF-7 xenografts in nude mice upon treatment by camptothecin. The skipping of exons that contain proteolytic clea...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1983
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(17)44226-8